Study of the stability of samples in oral solution containing human chorionic gonadotropin (HCG) as active principle

Abstract

Gonadotropic Chorionic Hormone (HCG) increases the metabolism of lipid emulsions accelerating fat oxidation and has been used in dietary treatments promoting loss of body fat. HCG may be administered intramuscularly or sublingually. The objective of this work was to evaluate the stability of HCG oral solution samples stored under different conditions. Oral solution samples containing HCG were obtained from a handling pharmacy in the north of Minas Gerais. Samples were diluted 1:200 in saline and stored at 8°C or room temperature (27°C). For 8 weeks the qualitative HCG screening of the samples was performed by Enzyme-Linked Immunosorbent Assay. Samples stored at 8°C and room temperature remained positive suggesting that there was no loss of HCG during the period evaluated. The results show that the storage forms evaluated do not interfere with the concentration of the active principle suggesting the maintenance of its effectiveness.